A network pharmacological approach to investigate the pharmacological effects of CZ2HF decoction on Alzheimer's disease

Background Alzheimer's disease (AD) is the most common type of dementia, which brings tremendous burden to sufferers and society. However, ideal tactics are unavailable for AD. Our previous study has shown that CZ2HF, a Chinese herb preparation, mitigates cognitive impairment in AD rats; whereas, its detailed mechanism not been elucidated. Methods Public databases were applied collect identify chemical ingredients eight herbs CZ2HF. Criteria absorption, distribution, metabolism, excretion was used screen oral bio‐availability drug‐likeness. STITCH database Therapeutic Target Database decipher relationship between compounds genes related Kyoto Encyclopedia Genes Genomes Gene Ontology term analyses involved signaling pathways. Cytoscape adopted establish networks The molecular docking validate interactions candidate their potential targets. Results 914 identified herbal medicines Among them, 9 28 highly pathologic process Furthermore, CZ2HF based on anti‐inflammatory effects mainly through lipopolysaccharide‐mediated pathway TNF pathway. Core this network TNF, ICAM1, MMP9 IL‐10. Conclusion This predicts active uncovers protein targets using holistic pharmacology methods. It will provide insight into underlying from multi‐scale perspective.